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KMID : 0363620120330030033
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Journal of Korean Oriental Medicine
2012 Volume.33 No. 3 p.33 ~ p.45
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The Effects in Metabolism and Adipose Tissue Inflammation Induced by the Massa Medicata Fermentata on Obese Type 2 Diabetes Mouse Model
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Paik Sun-Ho
Han Su-Ryun
Kwon Oh-Jun
Ahn Young-Min
Ahn Se-Young
Lee Byung-Cheol
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Abstract
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Objectives: Recent data have revealed that the plasma concentration of inflammatory mediators is increased in the insulin-resistant states of obesity and type 2 diabetes. The purpose of this study was to investigate the antidiabetic and anti-obesity effect of Massa Medicata Fermentata on obese type 2 diabetes mice.
Methods: In order to examine the effects of Massa Medicata Fermentata, obese type 2 diabetes mice induced by Surwit's high fat, high sucrose diet. Mice were divided into 4 groups of ND (normal diet), HFD (high fat and high sucrose diet), Met (high fat and high sucrose diet with metformin) and MMF (high fat and high sucrose diet with Massa Medicata Fermentata) and investigated over 8 weeks. Diabetic and obese clinical markers, including body weight, glucose level, lipid level, leptin concentration, epididymal fat pad and liver weights and adipose tissue macrophage (ATM) were determined.
Results: Compared with the HFD group, body weight, fructosamine, triglyceride, epididymal fat pad weight and ATM were significantly reduced in the MMF group.
Conclusions: From the above results, the intake of Massa Medicata Fermentata may be effective in anti-hyperglycemia and anti-obesity by the attenuation of glucose and lipid levels and also inflammation state. Massa Medicata Fermentata may be beneficial for controlling diabetes mellitus type 2 in humans.
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KEYWORD
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Massa Medicata Fermentata , type 2 diabetes , insulin resistance , obesity , adipose tissue , inflammation
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